1. The Drug Metabolism Section deeply regrets the untimely death of its devoted treasurer Prof. Grant Wilkinson in May 2006. Prof. Wilkinson served the section for many years and made major contributions to the section's activities in developing countries.
2. The DMS Council and General Assembly meetings were held in July 2006 during the 15th World Congress of Pharmacology in Beijing, China. A new council was elected, and several future activities were suggested by the section (see the enclosed minutes).
3. The DMS provided financial support ($5,000) to the International Conference in Pharmacogenetics (Changsha, China), a satellite meeting of the 15th World Congress of Pharmacology. Prof. John Miners, past Chair of the DMS, was one of the organizers of this meeting.
4. Possible collaboration between the DMS and the Division of Clinical Pharmacology on pharmacogenetics was discussed during 2006 (Patrich du Souich, Ingolf Cascorbi). This collaboration is a high priority item in the agenda of the DMS.
1. Dr. Collen Masimirembwa, CSO and Founder of AiBST, is asking for IUPHAR support to issue a hard copy of their Newsletter, for wide distribution in Africa. The DMS strongly supports this initiative and, again, asks for IUPHAR's support in the framework of its African initiative.
2. The planned Balkan's Workshop in Ochrid, FYROM, had to be postponed for various reasons, but especially because the EU could not secure support for this meeting. Section members have been active in trying to further this important meeting series. It is now envisaged that the next workshop will be held in 2008 in Novi Sad, Serbia.
3. The DMS is currently planning additional meetings in developing countries (as detailed in the Beijing DMS meeting minutes.
Prof. Jaime Kapitulnik, Chair Prof. Olavi Pelkonen, Secretary
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Minutes of the general meeting of the Drug Metabolism Section of IUPHAR
Beijing, China – July 4, 2006
The general meeting of the DMS was held on July 4, 2006 at the 15th World Congress of Pharmacology (Beijing, China, July 2-7, 2006). Eleven section members participated in the meeting. Prof. Olavi Pelkonen was not able to attend and sent his apologies.
Prof. John Miners (Chair of the DMS) opened the meeting and reported on the activities of the DMS during the past four years. The DMS sponsored workshops in developing countries (for details see the DMS report in the IUPHAR website). The Balkans workshop planed for 2006 was postponed by the organizers to 2007. The DMS sponsored the International Conference in Pharmacogenetics, a satellite meeting of the 15th World Congress of Pharmacology. The DMS will consider sponsoring future workshops in South Africa, Southeast Asia or India, and South America.
The DMS was very active and successful in submitting proposals for symposia and plenary lectures in IUPHAR-related meetings (CPT Congress in Brisbane and World Congress of Pharmacology in Beijing).
Dr. Paul Erhardt (University of Toledo) submitted to the DMS an interim report on a project aimed to establish a Human Drug Metabolism Database. This pilot project was supported by a grant from ICSU, received by the DMS with the help of IUPHAR. The database is in a very initial phase, and additional financial support is required to advance it.
Prof. Miners highlighted the good financial status of the DMS (actual balance: $36,598.96). The optimal financial performance of the DMS is a direct result of the outstanding contribution of its treasurer, Prof. Grant Wilkinson, who has passed away recently. The DMS mourns his untimely death and sends condolences to the family. A Grant Wilkinson Scholarship ($1,500) will be established by the DMS to allow a student from a developing country to attend an international drug metabolism meeting.
Prof. Miners acknowledged the contributions of the members of the DMS Executive Committee who completed their terms in office: Profs. Gabrielle Hawksworth, Stanislav Yanev, Yuichi Sugiyama and Philippe Beaune.
Prof. Miners presented a proposal for the new Executive Committee of the DMS (2006 – 2010), which retains its geographical balance:
Chair |
Prof. Jaime Kapitulnik, Israel |
Secretary |
Prof. Olavi Pelkonen, Finland |
Vice-Chair |
Prof. Allan Rettie, USA |
Treasurer |
Prof. Steven Leeder, USA |
Councillors |
Prof. Mumtaz Iscan, Turkey |
 |
Prof. Aldo Mottino, Argentina |
|
Dr. Amin Rostami-Hodjegan, UK |
|
Prof. H. Suzuki, Japan |
|
Prof. Andrew Walubo, South Africa |
|
Prof. Hong-Hao Zhou, China |
Past Chair |
Prof. John Miners, Australia |
The proposed committee was approved unanimously. It was agreed to have 6-9 councillors, if the IUPHAR statutes allow it. Another option was to have co-opting members in the Executive Committee.
Prof. Stanislav Yanev reported that the Balkans workshop in Skopje (Albania) will host scientists from many Balkan countries. The organizers decided to postpone the workshop to 2007 because they applied too late for financial support and there was uncertainty about funding sources. Eurotox will sponsor a special session on risk assessment and the COST program of the EU will consider additional support. The final decision about holding the meeting will be taken in another 2 months.
Prof. Miners passed the chair to Prof. Kapitulnik, the newly elected chair. Prof. Kapitulnik thanked the DMS members for their vote of confidence, and Profs. Miners, Hawksworth and Birkett (the previous DMS chairs) for their contributions to the Section. He also highlighted the excellent work done by Prof. Pelkonen in his first term as secretary of the Section.
One of Prof. Kapitulnik's main goals is to increase the involvement of the DMS in the activities of IUPHAR and establish a close collaboration with the Division of Clinical Pharmacology. He will also try to interest more scientists in the drug metabolism area to join the Section and contribute to its activities. Profs. Kapitulnik and Leeder will act to increase the yearly IUPHAR allocation for the DMS beyond $5,000 and to receive it on a more regular basis.
Kathy Knights asked if there was an e-mail list of DMS members. Prof. Kapitulnik responded that Prof. Pelkonen is starting to develop a list, which can increase the roster of active members by assigning specific tasks to DMS members.
Gabrielle Hawksworth suggested working with IUTOX for coordinating new programs for developing countries. She also suggested that we keep an eye on deadlines for submission of proposals for symposia in pharmacology and other meetings.
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Report of the IUPHAR Section on Drug Metabolism to Executive Committee - April, 2005
Report from the IUPHAR Section of Drug Metabolism for 2004
Chair |
Prof John Miners (Australia) |
Secretary |
Prof Olavi Pelkonen (Finland) |
Vice-Chair |
Prof Jaime Kapitulnik (Israel) |
Treasurer |
Prof Grant Wilkinson (USA) |
Councillors |
Prof Andrew Walubo (South Africa) |
|
Prof Aldo Mottino (Argentina) |
|
Prof Philip Beaune (France) |
|
Prof Hong-Hao Zhou (China) |
|
Prof Yuichi Sugiyama (Japan) |
|
Prof Stanislav Yanev (Bulgaria) |
Past Chair |
Prof Gabrielle Hawksworth (UK) |
The officers were elected by the General Meeting of the Section held during the 14th International Congress of Pharmacology in San Francisco in 2002. They provide broad geographical representation and areas of expertise.
Section - sponsored meetings and workshops
The Section's activities have largely focussed on its primary remit: to promote drug metabolism activities in developing countries and at IUPHAR-supported international meetings. Indeed, given the demand for support of meetings in developing countries, the Section has recently formulated guidelines for assessing applications for the funding of regional activities. These guidelines can be found at the IUPHAR Web pages (http://www.iuphar.org)
The Section-sponsored Drug Metabolism Workshops in developing countries have concentrated on two geographical areas, the Balkans and Africa, due largely to perceived benefit, local demand and the enthusiasm of the local organisers and participants. Details of section-sponsored meetings are outlined below.
The 6th Xenobiotic Metabolism and Toxicity Workshop of Balkan Countries was held in Banja Luka, Bosnia and Herzegovina on June 16 -19, 2004, and focussed on research activities in the areas of xenobiotic metabolism in the Balkan countries, as well as regulatory considerations (including bioequivalence studies). The workshop included two poster sessions and a hands-on demonstration of pharmacokinetic modelling, organized by Dr Amin Rostami-Hodjegan (University of Sheffield). The chair of the local organising committee was Professor R Skrbic. As with the previous workshop, there were over 100 participants at this workshop representing most Balkan countries. There were also plenary lectures presented by outside speakers and a session sponsored through the COST Action B15 on "Changing methodologies to study drug metabolism and pharmacokinetics in drug development". The next Balkan Congress will be held in Ohrid, Macedonia, in May-June 2006.
The Section has obtained evaluations and feedback from previous organizers of the Balkans Workshops, and a report will be prepared shortly.
A workshop on Pharmacokinetics and Research Ethics was held at the School of Medicine, Faculty of Health Sciences, University of the Free State, Bloemfontein in South Africa from 6th to 8th December 2004. It was hosted by the Department of Pharmacology under the auspices of the African Society for Drug Metabolism and Development, and chaired by Prof Andrew Walubo. Originally the workshop was planned to be held in Nigeria but, due to unexpected circumstances, the location had to be moved to Bloemfontein at a very short notice. The aim of the workshop was to guide young scientists and researchers on how to undertake pharmacokinetics studies with high ethical standards, hence the theme, "Pharmacokinetics and Research Ethics". There were 32 participants from South Africa, Rwanda, Mozambique, Kenya, and Tanzania. Participants' evaluation was largely very positive.
The Section is supporting another workshop ('Drug Metabolism in Clinical Trials Design'), to be hosted by the African Institute for Biomedical Science and Technology in 2005.
The Section is involved in the planning of a workshop on Pharmacogenetics. The workshop will be held in China during 2006 as a satellite of the 15th World Congress of Pharmacology. The workshop will be co-sponsored by the Southeast Asian Western Pacific Regional Federation of Pharmacologists and the Pacific Rim Association for Clinical Pharmacogenetics.
In summary, the workshops to promote drug metabolism activities in developing countries have been an outstanding success at a regional level, and there is continuing enthusiasm for future workshops. The workshops obviously pose a challenge for raising funds, and this is even more difficult in developing countries. Generally, at least 70-80% of the funding for these workshops has to be raised from outside IUPHAR, but the seed funding from the Section is extremely valuable for initiating the meetings. The Section wishes to acknowledge the role of Professor Grant Wilkinson, as Treasurer, in raising funds to support the workshops in developing countries.
IUPHAR Congresses
Members of the Section contributed to the organisation of the 8th World Conference on Clinical Pharmacology and Therapeutics held in Brisbane, Queensland, Australia from1-6 August 2004. Drug metabolism and disposition was well represented on the meeting program, and feedback regarding the content and quality of sessions was highly favourable. An informal meeting of the Section Executive was held during the course of the Congress.
The Section has been active in submitting suggestions for symposia for inclusion in the program of the 15th World Congress of Pharmacology (Beijing, 2006).
Other initiatives
In 2001 the Section received a grant from ICSU for $50,000 for a project, Enhancing Global Input into a Human Drug Metabolism Database'. This is a collaborative project to develop a database that extends the collection of drug metabolism data beyond the large pharmaceutical companies. The project is coordinated by Dr Paul Erhardt, University of Toledo, Ohio, USA. The focus initially is on anticancer drugs. A meeting was held with Dr Erhardt in 2004 to assess the progress of the project.
Section account - 2004
Thanks largely to the efforts of the Treasurer, Professor Grant Wilkinson, the opening balance of the Section's account (held by the American Society for Pharmacology and Experimental Therapeutics) was $36,148.15. Interest earned during 2004 was $347.58. Expenditure totalled $3,800, which comprised the annual account maintenance fee ($300) and workshop seeding funds ($3,500). The end of year balance was $32,695.73. Although the Section has been able to raise funds from external sources in the past, more recent attempts to obtain corporate sponsorship have been unsuccessful and this will ultimately impact on the Section's ability to support symposia and workshops.
JOHN MINERS
Section Chair
OLAVI PELKONEN
Section Secretary
March 2005
