PHARMACOLOGY I (3rd year / Winter semester, 13 weeks, 4 hrs/week)
A. GENERAL PHARMACOLOGY
Drugs, pharmacology, and medicine
Principles of pharmacology
The fate of drugs in the organism
Drug administration
Drug absorption
Drug distribution
Drug metabolism
Drug interactions
Drug elimination
Factors affecting pharmacokinetics
Pharmacodynamics: the effect of the drug on the body
Site of action of drugs in the body
Mechanisms of drug action
Drug receptors
Dosing and therapeutical index
Dose-response relationship
Issues of drug safety and toxicity
Therapeutic levels of drugs / therapeutic window
Factors affecting drug safety and efficacy
Agonists and antagonists
Drug synergy and antagonism
Drug resistance
Adverse drug reactions
Types of drug allergies
Idiosyncratic responses to drugs
Individual responses to drugs / Pharmacogenetics
Drug tolerance
Drug dependence and drug abuse
B.SYSTEMS PHARMACOLOGY
Introduction to autonomic pharmacology
Cholinergic transmission, parasympathomimetics
Anticholinergic agents, Parasympatholytics
Adrenergic transmission, sympathomimetics
Adrenolytic agents, sympatholytics
Beta blockers
Ganglion blockers and stimulants
Skeletal neuromuscular blocking agents
Peptides, histamine, angiotensin, prostaglandins)
Antagonists of histamine
Introduction to CNS pharmacology
CNS stimulants
CNS blockers
Neuroleptic agents
Anxiolytic and Hypnotic agents
Anti epileptic agents
Drugs used in Parkinsonism
PHARMACOLOGY II (3rd year / Spring semester, 13 weeks, 4 hrs/week)
B. SYSTEMS PHARMACOLOGY (cond)
Introduction to analgesic drugs
General anaesthetics
Narcotic analgesics
Antagonists of narcotic analgesics
Non-narcotic analgesics, NSAIDs
Local anaestetics
Overview of therapeutics of the cardiovascular system
Digitalis and other drugs used in heart failure
Antiarrythmic agents
Drugs used in angina
Antihypertensive agents
Diuretics
Drugs affecting blood coagulation
Lipid-lowering drugs
Antiasthmatic agents
Basic principles of chemotherapy
Beta-lactam antibiotics I: Penicillins
Beta-lactam antibiotics II: Cephalosporins
Beta-lactam antibiotics III: Monovactams, Penems-carvapenems
Beta-lactam blockers
Inhibitors of bacterial protein synthesis I: Aminoglycosides
Inhibitors of microbial protein synthesis II: Tetracyclines
Inhibitors of bacterial protein synthesis III: Macrolides and chloramphenicol
Sulfonamides
Nitroimidazoles
Quinolones
Antimycobacterial agents
Drugs acting on parasites
Antifungal agents
Antiviral agents
Anticancer drugs
Thyroid and antithyroid drugs
Insulin and other antidiabetic agents
Sex hormones and drugs
Water-solube vitamins
Lipid-soluble vitamins