The general goals of this pharmacology/pharmacotherapy education is to provide the student sufficient knowledge so that he will be able to make responsible judgements about the risks and benefits of single use or combination used medicines per patient, and to be able to follow the changes in the field of pharmacotherapy later as a physician.
General Pharmacology
Goals
To be able to reproduce basic pharmacological definitions;
To be able to summarise the cellular and intracellular working mechanism of drugs;
To have knowledge of drug-receptor interactions and concentration-response relationships;
To have knowledge about dose-response relationships;
The knowledge of quantitative pharmacokinetic parameters;
To be able to describe the principles involved in the absorption, distribution, metabolism and
excretion of drugs;
To have knowledge of neurotransmittors and receptors of the autonomous nervous system;
To have knowledge of serotonin and serotonin receptors;
To have an overview of the mechanism of action, the pharmacological effects, the therapeutic
use and the side-effects of cholinomimetics, antimuscarinic drugs, adrenomimetics, adrenolytics,
cholinesterase blockers, ganglion blocking substances and substances which act on serotonin
receptors.
Endocrinology and metabolism
After studying the pharmacological/pharmacotherapeutical matter related to this part, the student
should have sufficient knowledge of the principles, the mechanism of action and and the indications
and contraindications of medicine-groups, including several prototype medicines, used for disorders
of the following endocrine systems:
Adrenal cortex: glucocorticosteroids (cortisol, prednisolone, dexamethasone);
Subthalamus/hypophysis: gonadoreline, octreotide, somatostatin, somatropin, TSH, ACTH,
gonadotropine, bromocriptine, oxytocin, vasopressin.
Endocrine pancreas: different insulins, tolbutamide, glibenclamide, metformin, glucagon
Thyroid: thyroxine, liothyronine, propylthiouracil, iodine
After studying the pharmacological/pharmacotherapeutical matter related to this part the student should have sufficient knowledge of the principles, the mechanism of action and of the indications and contraindications of medicine-groups and their most important side-effects, including several prototype medicines and their uses.
In addition:
bone manufacture: calcitonin, bifosfonaten, ergocalciferol;
benign prostate overgrowth: cyproterone, finasteride,
are dealt with.
Blood elements
After studying of the pharmacological/pharmacotherapeutical matter related to this part, the
student should have sufficient knowledge of the principles, the mechanism of action and the
indications and contraindications of medicine-groups and their most important side-effects, including
several prototype medicines, used by treatment of:
anaemia, neutropenia and thrombopenia: cyanocobalamin, folic acid, iron, erytropoietin,
filgrastim, prednisolone
Cancer chemotherapy
After studying of the pharmacological/pharmacotherapeutical matter related to this part, the
student should have sufficient knowledge of the principles and the side-effects of the medicine-
groups, including several prototype medicines, used by treatment of:
malignant illnesses: cyclophosphamide, methotrexate, doxorubicine, 5-FU, vincristine,
tamoxifwn, cisplatin, prednisolon
Antimicrobial agents
After studying of the pharmacological/pharmacotherapeutical matter related to this part, the
student should have sufficient knowledge of the principles, the mechanism of action and the
indications and contraindications of medicine-groups and their most important side-effects, including
several prototype medicines, used by treatment of:
Bacterial infections: penicillin G, feneticillin, amoxicillin, flucloxacillin, ticarcillin, piperacillin,
clavulanic acid, cefalexine, cefalotine, cefotaxim, ceftazidim, tetracycline, doxycycline,
ciprofloxacine, chloramphenicol, tobramicine, erythromycine, clindamycine, vancomycine,
metronidazol, sulfafurazol, trimetroprim, co-trimoxazol, nitrofurantoine, rifampicine, INH, dapsone
Helminthiasis infections: albendazol, praziquantel
Protozoal infections: kinine, choloroquine, meflquine, halofantrine, metronidazol
Viral infections: acyclovir
Fungal infections: nystatine, amphotericine B, ketoconazole
Immunopharmacology
After studying of the pharmacological/pharmacotherapeutical matter related to this part, the
student should have sufficient knowledge of the principles, the mechanism of action and the
indications and contraindications of medicine-groups and their most important side-effects, including
several prototype medicines, used by treatment of:
Allergic illnesses: astemizaol, terfenadine, cromoglicine acid
Diseases that make influencing the immunity system necessary: cyclosporine, azathioprine,
prednisolone
Cardiovascular pharmacology
After studying of the pharmacological/pharmacotherapeutical matter related to this part, the
student should have sufficient knowledge of the principles, the mechanism of action and the
indications and contraindications of medicine-groups and their most important side-effects, including
several prototype medicines, used by treatment of:
Conditions that make influencing the lipidemia of the blood necessary: simvastatine, gemfibrozil
Diseases that make influencing the coagulation necessary: vitamin K, heparin, acenocoumarol,
aspirin, TPA, streptokinase
Stenocardia: nitroglycerin, isosorbide dinitraat, atenolol, nifedipine
Hyperpiesis: hydrochloorthiazide, amiloride, nifedipine, captopril, atenolol, prazosine,
Currently under development is the pharmacotherapy in the theoretical small-scale education
program:
This involved the development of pharmacology content in a variety of tutorials including:
DMI; fever in an infant; spastic colon; anaemia in an infant; Crohns disease; pneumococ
pneumonia; pneumothorax; chest pains; coughing infant; angina; 89 year old dyspenic male.