Department of pharmacology, School of Medicine, University of Patras, Patras, Greece

Contact: Michael Maragoudakis, Professor: E-mail: HYPERLINK mailto:maragoud@med,upatras.gr maragoud@med,upatras.gr

UnderGraduate Courses

PHARMACOLOGY I (Fall semester course, Third year)
Introduction to Pharmacology
Pharmacokinetics.
Pharmacodynamics: Drug receptors, principles, agonists and antagonists, quantitative aspects.
Principles of Therapeutics

Nervous Systems
Somatic motor system, competitive and depolarizing blocking agents;
Physiology of the autonomic and somatic nervous systems;
Neurotransmitters, synthesis, storage, metabolism, classification of receptors;
Parasympathetic nervous system, cholinergic drugs, anticholinesterases, muscarinic blocking agents;
Somatic motor system, competitive and depolarizing blocking agents;
Sympathetic nervous system, a/b-receptor stimulants and their clinical applications; b-Blocking agents and clinical applications;

Autocoids
Histamine and its physiological effects, antagonists at H1, H2 receptors and H3 receptors;
Prostaglandins;
Serotonin, its formation and pharmacological action; 5HT antagonists;
Kinins, location, physiology, receptors, the Kallikrein/Kinin system; the renin angiotensin system;

Central nervous system
Neurotransmission and the CNS
Parkinson's disease and its treatment;
Anxiety disorders and their treatment;
Mental illness, psychoses and relevant therapeutic agents;
Hypnotics and sedatives ; Ethanol
Epilepsy - diagnosis, classification and therapy;

PHARMACOLOGY II (Spring semester course, Third year)
Local anaesthetics, mechanism of action; Types of local anaesthesia.
Anaesthesia - different stages, anaesthetic agents;
Physiology of pain, pain pathways; Naturally occurring opioids, action on brain and peripheral tissues; Morphine receptor antagonists; Drug dependence - psychological and physical addiction, withdrawal symptoms; drugs and agents associated with dependence;
Non steroid-anti-inflammatory agents

Cardiovascular system
Circulation and cardiac function; cardiac action potential, cardiac homeostasis, treatment of ischaemic heart disease; control of calcium channels, cardiac insufficiency and dysrhythmias, and drugs used in treatment.
Lipids and lipid lowering drugs.
Renal physiology and diuretics;
Hypertension - aetiology, diagnosis, essential and renal hypertension; acute hypertension; drugs used in treatment;
Blood, coagulation, clotting factors, role of platelets, haemophilia, anticoagulants, antiaggregatory agents, physiological clot dissolution, plasmin, streptokinase, tPA;.

Respiratory physiology; drugs used in respiratory conditions.

Physiology of the gastrointestinal tract and drugs used in conditions such as ulcers, constipation, gallstones, haemorrhoids, diarrhoea, inflammatory bowel disease.

Endocrinology - the role of the hypothalamus and pituitary; hormones:
Drugs affecting corticosteroid synthesis and their uses; Mineralocorticoids;
Structure, action and release and therapeutic use of growth hormone;
Disorders of the thyroid gland and therapy;
Pancreas, insulin structure, mechanism of action; glucagon and its effects; Diabetes Mellitus and its treatment;
Male and female reproductive system, control of reproduction;
Hypothalamus and pituitary systems; Therapeutic uses of oestrogens and progestagens; Treatment of menopausal symptoms; Hormonal and non-hormonal contraceptive agents and devices;

Chemotherapy
Antimicrobial therapy including mechanisms of action of the main antimicrobial agents.
Fungal diseases and their treatment; Protozoal diseases and treatment; Malaria and antimalarial drugs.
Neoplastic diseases and their treatment;

Drug interactions;

Environmental toxicology including heavy metals, food additives, solvents and industrial diseases;

Graduate courses are under development Our post-graduated program has two directions: Pharmacokinetics and Toxicology leading after twoyears in MSc that can be extented to Ph.D. This program has been introduced this year and the courses to be taught are under development.

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